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Combination Therapy Produces Synergistic EffectsThe use of several different products allows slightly lower doses, which diminishes the risk for side effects.When benzoyl peroxide is combined with an antibiotic, the antibiotic minimizes benzoyl peroxide irritation by controlling inflammation and the benzoyl peroxide reduces the risk of antibiotic resistance by killing resistant strains of bacteria.Antibiotics can also reduce erythema in patients whose skin is irritated by the harsher topical retinoids.Adapalene, the least irritating of the topical retinoids, has anti-inflammatory effects that can be enhanced by the addition of an antibiotic.

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